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KMID : 0388720210280040116
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Journal of Korean Society of Spine Surgery
2021 Volume.28 No. 4 p.116 ~ p.122
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Effect of Denosumab in Primary Osteoporosis Patients According to Their Bisphosphonate Response
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Ha Dae-Ho
Oh Sung-Kyun
Han Byeol
Kim Tae-Kyun
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Abstract
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Purpose: The purpose of this study was to investigate the effect of denosumab in patients with primary osteoporosis according to their response to bisphosphonates (BP).
Summary of Literature Review: Even with BP treatment, the T-score for bone mineral density (BMD) decreased by 8-25%.
Materials and Methods: Among patients treated with BP for more than 2 years, those with a decrease of more than the least significant change in the mean T-score of the lumbar spine or femur on a BMD test were defined as non-responders to BP. Nonresponders were switched to denosumab and we investigated the changes in their T-score through a BMD test 1 year later. Nine patients were classified as non-responders, while 253 patients who responded to BP and switched to denosumab injections were classified as responders.
Results: One year later, the mean spine T-score of non-responders improved by 8.4% from -2.63 to -2.41 (p=0.0148), and the T-score of responders also improved by 14.4% from -2.16 to -1.85. For the femur neck, the mean T-score of non-responders improved by 0.3% from -3.80 to -3.79 (p=0.3781), and the mean T-score of responders improved by 4.8% from -3.11 to -2.96 (p<0.001).
Conclusions: In non-responsive patients with no increase in the T-score even after BP treatment, an increase in the T-score was observed after a transition to denosumab injections.
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KEYWORD
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Osteoporosis, Bisphosphonate, Denosumab
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